"Increased amino acid supplementation (0.5x, 1.0x, and 5.0x recommended concentrations or additional proline) was hypothesized to increase the collagen content in engineered cartilage. No significant differences were found between groups in matrix content or dynamic modulus," scientists in the United States report (see also Engineered Cartilage).
"Control constructs possessed the highest compressive Young's modulus on day 42. On day 42, compared to controls, decreased type II collagen was found with 0.5x, 1.0x, and 5.0x supplementation and significantly increased DNA content found in 1.0x and 5.0x. No effects were observed on these measures with added proline. These …
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